Synthesis and Biological Evaluation of Novel 2-Arylalkylthio-5-iodine-6-substituted-benzyl-pyrimidine-4(3H)-ones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

Synthesis and Biological Evaluation of Novel 2-Arylalkylthio-5-iodine-6-substituted-benzyl-pyrimidine-4(3H)-ones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

A novel series of 2-arylalkylthio-5-iodine-6-substitutedbenzyl-pyrimidine-4(3H)-ones (S-DABOs) 8a–x had been synthesized via an efficient method. Their biological activity against HIV virus and RT assay were evaluated. Some compounds, especially 8h, 8l and 8n, displayed promising activity against HI...

Full description

Bibliographic Details
Main Authors: Liang Zhang, Xiaowan Tang, Yuanyuan Cao, Shaotong Wu, Yu Zhang, Jianxiong Zhao, Ying Guo, Chao Tian, Zhili Zhang, Junyi Liu, Xiaowei Wang
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Molecules
Subjects:
HIV
NNRTIs
S-DABOs
IC50
docking
Online Access:http://www.mdpi.com/1420-3049/19/6/7104

Internet

http://www.mdpi.com/1420-3049/19/6/7104

Similar Items