Understanding the key features of the spontaneous formation of bona fide prions through a novel methodology that enables their swift and consistent generation

Understanding the key features of the spontaneous formation of bona fide prions through a novel methodology that enables their swift and consistent generation

Abstract Among transmissible spongiform encephalopathies or prion diseases affecting humans, sporadic forms such as sporadic Creutzfeldt–Jakob disease are the vast majority. Unlike genetic or acquired forms of the disease, these idiopathic forms occur seemingly due to a random event of spontaneous m...

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Bibliographic Details
Main Authors: Hasier Eraña, Carlos M. Díaz-Domínguez, Jorge M. Charco, Enric Vidal, Ezequiel González-Miranda, Miguel A. Pérez-Castro, Patricia Piñeiro, Rafael López-Moreno, Cristina Sampedro-Torres-Quevedo, Leire Fernández-Veiga, Juan Tasis-Galarza, Nuria L. Lorenzo, Aileen Santini-Santiago, Melisa Lázaro, Sandra García-Martínez, Nuno Gonçalves-Anjo, Maitena San-Juan-Ansoleaga, Josu Galarza-Ahumada, Eva Fernández-Muñoz, Samanta Giler, Mikel Valle, Glenn C. Telling, Mariví Geijó, Jesús R. Requena, Joaquín Castilla
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Acta Neuropathologica Communications
Subjects:
Prion
Transmissible spongiform encephalopathies
Spontaneous misfolding
Strain
Online Access:https://doi.org/10.1186/s40478-023-01640-8

Internet

https://doi.org/10.1186/s40478-023-01640-8

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