MicroRNA-527 inhibits TGF-β/SMAD induced epithelial-mesenchymal transition via downregulating SULF2 expression in non-small-cell lung cancer

MicroRNA-527 inhibits TGF-β/SMAD induced epithelial-mesenchymal transition via downregulating SULF2 expression in non-small-cell lung cancer

Objective To explore the potential mechanism which miR-527 targeting the heparan sulfate 6-O-endosulfatase (SULF2) regulates TGF-β/SMAD signaling pathway induced epithelial-mesenchymal transition (EMT) in non-small-cell lung cancer (NSCLC). Methods 38 pairs of lung tumor biopsies and corresponding p...

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Bibliographic Details
Main Authors: Wei Huo, Xiao-Min Zhu, Xin-Yan Pan, Min Du, Zhuo Sun, Zhi-Min Li
Format: Article
Language:English
Published: AIMS Press 2019-05-01
Series:Mathematical Biosciences and Engineering
Subjects:
mir-527
sulf2
tgf-β/smad signaling pathway
nsclc
emt
Online Access:https://www.aimspress.com/article/10.3934/mbe.2019231?viewType=HTML

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https://www.aimspress.com/article/10.3934/mbe.2019231?viewType=HTML

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