Monocyte-derived alveolar macrophages are key drivers of smoke-induced lung inflammation and tissue remodeling

Monocyte-derived alveolar macrophages are key drivers of smoke-induced lung inflammation and tissue remodeling

Smoking is a leading risk factor of chronic obstructive pulmonary disease (COPD), that is characterized by chronic lung inflammation, tissue remodeling and emphysema. Although inflammation is critical to COPD pathogenesis, the cellular and molecular basis underlying smoking-induced lung inflammation...

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Bibliographic Details
Main Authors: Christian T. Wohnhaas, Kevin Baßler, Carolin K. Watson, Yang Shen, Germán G. Leparc, Cornelia Tilp, Fabian Heinemann, David Kind, Birgit Stierstorfer, Denis Delić, Thomas Brunner, Florian Gantner, Joachim L. Schultze, Coralie Viollet, Patrick Baum
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
monocyte-derived alveolar macrophages
single-cell RNA-sequencing
COPD
lung inflammation
IRAK4 inhibitor
neutrophils
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1325090/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1325090/full

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