Impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress

Impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress

Though the facilitating influence of stress on drug abuse is well documented, the mechanisms underlying this interaction have yet to be fully elucidated. The present study explores the neurobiological mechanisms underpinning the sensitized response to the psychomotor-stimulating effects of cocaine f...

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Bibliographic Details
Main Authors: María P. Avalos, Andrea S. Guzman, Constanza Garcia-Keller, Bethania Mongi-Bragato, María A. Esparza, Daiana Rigoni, Marianela A. Sanchez, Gastón D. Calfa, Flavia A. Bollati, Liliana M. Cancela
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Physiology
Subjects:
chronic restraint stress
ceftriaxone
cocaine
dendritic spines
GLT-1
glutamate
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.896268/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.896268/full

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