The effect of human PBMCs immobilization on their Аβ42 aggregates-dependent proinflammatory state on a cellular model of Alzheimer’s disease

The effect of human PBMCs immobilization on their Аβ42 aggregates-dependent proinflammatory state on a cellular model of Alzheimer’s disease

The leading pathological mechanisms of Alzheimer’s disease are amyloidosis and inflammation. The presented work was aimed to study the effect of human peripheral blood mononuclear cells (hPBMcs) cells-matrix adhesion on their pro-inflammatory state in vitro. Although direct interaction of Аβ42 to PB...

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Bibliographic Details
Main Authors: Kateryna Kot, Yurii Kot, Rustam Kurbanov, Hanna Andriiash, Olena Tigunova, Yaroslav Blume, Sergiy Shulga
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
Аβ42 aggregates
hPBMCs
β1 integrins
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1325287/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2024.1325287/full

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