Macrophage replication screen identifies a novel Francisella hydroperoxide resistance protein involved in virulence.

Francisella tularensis is a gram-negative facultative intracellular pathogen and the causative agent of tularemia. Recently, genome-wide screens have identified Francisella genes required for virulence in mice. However, the mechanisms by which most of the corresponding proteins contribute to pathoge...

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Bibliographic Details
Main Authors: Anna C Llewellyn, Crystal L Jones, Brooke A Napier, James E Bina, David S Weiss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3167825?pdf=render