Sulforaphane Combined with Vitamin D Induces Cytotoxicity Mediated by Oxidative Stress, DNA Damage, Autophagy, and JNK/MAPK Pathway Modulation in Human Prostate Tumor Cells

Sulforaphane Combined with Vitamin D Induces Cytotoxicity Mediated by Oxidative Stress, DNA Damage, Autophagy, and JNK/MAPK Pathway Modulation in Human Prostate Tumor Cells

Prostate cancer ranks second in incidence worldwide. To date, there are no available therapies to effectively treat advanced and metastatic prostate cancer. Sulforaphane and vitamin D alone are promising anticancer agents in vitro and in vivo, but their low bioavailability has limited their effects...

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Bibliographic Details
Main Authors: Katiuska Tuttis, Ana Rita Thomazela Machado, Patrick Wellington da Silva Santos, Lusânia Maria Greggi Antunes
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Nutrients
Subjects:
calcitriol
nutrigenomics
chemoprevention
nutraceuticals
Online Access:https://www.mdpi.com/2072-6643/15/12/2742

Internet

https://www.mdpi.com/2072-6643/15/12/2742

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