MxB sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface

MxB sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface

The type one interferon induced restriction factor Myxovirus resistance B (MxB) restricts HIV-1 nuclear entry evidenced by inhibition of 2-LTR but not linear forms of viral DNA. The HIV-1 capsid is the key determinant of MxB sensitivity and cofactor binding defective HIV-1 capsid mutants P90A (defec...

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Bibliographic Details
Main Authors: Richard J Miles, Claire Kerridge, Laura Hilditch, Christopher Monit, David A Jacques, Greg J Towers
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
HIV
capsid
cyclophilin A
restriction factor
MxB
Online Access:https://elifesciences.org/articles/56910

Internet

https://elifesciences.org/articles/56910

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