Platelet-activating factor and protease-activated receptor 2 cooperate to promote neutrophil recruitment and lung inflammation through nuclear factor-kappa B transactivation

Platelet-activating factor and protease-activated receptor 2 cooperate to promote neutrophil recruitment and lung inflammation through nuclear factor-kappa B transactivation

Abstract Although it is well established that platelet-activated receptor (PAF) and protease-activated receptor 2 (PAR2) play a pivotal role in the pathophysiology of lung and airway inflammatory diseases, a role for a PAR2-PAFR cooperation in lung inflammation has not been investigated. Here, we in...

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Bibliographic Details
Main Authors: Irismara Sousa Silva, Aline D. Almeida, Antônio C. M. Lima Filho, Weslley Fernandes-Braga, Ayslan Barra, Hortência M. C. Oliveira, Geovanni D. Cassali, Luciano S. A. Capettini, Gustavo B. Menezes, Jacqueline I. Alvarez-Leite, Maria F. Leite, André Klein
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-48365-1

Internet

https://doi.org/10.1038/s41598-023-48365-1

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