Heme Induces Endoplasmic Reticulum Stress (HIER Stress) in Human Aortic Smooth Muscle Cells

Heme Induces Endoplasmic Reticulum Stress (HIER Stress) in Human Aortic Smooth Muscle Cells

Accumulation of damaged or misfolded proteins resulted from oxidative protein modification induces endoplasmic reticulum (ER) stress by activating the pathways of unfolded protein response. In pathologic hemolytic conditions, extracellular free hemoglobin is submitted to rapid oxidation causing heme...

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Bibliographic Details
Main Authors: Tamás Gáll, Dávid Pethő, Annamária Nagy, Zoltán Hendrik, Gábor Méhes, László Potor, Magnus Gram, Bo Åkerström, Ann Smith, Péter Nagy, György Balla, József Balla
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Physiology
Subjects:
heme
vascular smooth muscle cell
heme induced endoplasmic reticulum stress
atherosclerosis
hemopexin
alpha-1-microglobulin
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01595/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.01595/full

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