IL-1β promotes osteoclastogenesis by increasing the expression of IGF2 and chemokines in non-osteoclastic cells

IL-1β promotes osteoclastogenesis by increasing the expression of IGF2 and chemokines in non-osteoclastic cells

Bone remodeling mediated by bone-forming osteoblasts (OBs) and bone-resorbing osteoclasts (OCs) maintains bone structure and function. Excessive OC activation leads to bone-destroying diseases such as osteoporosis and bone erosion of rheumatoid arthritis (RA). Differentiation of OCs from bone marrow...

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Bibliographic Details
Main Authors: Yuto Otsuka, Takao Kondo, Hiromasa Aoki, Yoh Goto, Yohei Kawaguchi, Yuko Waguri-Nagaya, Ken Miyazawa, Shigemi Goto, Mineyoshi Aoyama
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Journal of Pharmacological Sciences
Subjects:
Osteoclast
IL-1β
Chemokine
IGF2
Microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861322000822

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http://www.sciencedirect.com/science/article/pii/S1347861322000822

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