Reversible modulation of myofibroblast differentiation in adipose-derived mesenchymal stem cells.

Unregulated activity of myofibroblasts, highly contractile cells that deposit abundant extracellular matrix (ECM), leads to fibrosis. To study the modulation of myofibroblast activity, we used human adipose-derived mesenchymal stem cells (ADSCs), which have much potential in regenerative medicine. W...

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Bibliographic Details
Main Authors: Vivek D Desai, Henry C Hsia, Jean E Schwarzbauer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3900664?pdf=render