Lovastatin Alleviates Endothelial-to-Mesenchymal Transition in Glomeruli via Suppression of Oxidative Stress and TGF-β1 Signaling

Lovastatin Alleviates Endothelial-to-Mesenchymal Transition in Glomeruli via Suppression of Oxidative Stress and TGF-β1 Signaling

Statins may decrease chronic kidney diseases (CKDs) risk, but their underlying molecular mechanisms are not completely understood. Recent studies indicate Endothelial-to-mesenchymal transition (EndMT) plays an important role contributing to renal interstitial fibrosis. In the present study, we first...

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Bibliographic Details
Main Authors: Zejun Ma, Lili Zhu, Yan Liu, Zhida Wang, Yang Yang, Liming Chen, Qiulun Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Pharmacology
Subjects:
diabetic nephropathy
endothelial-to-mesenchymal transition
renal fibrosis
oxidative stress
lovastatin
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00473/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00473/full

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