Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages

Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages

Pathogenic microorganisms are sensed by the inflammasome, resulting in the release of the pro-immune and proinflammatory cytokine interleukin-1β (IL-1β). In humans, the paired sialic acid-binding Ig-like lectin receptors Siglec-5 (inhibitory) and Siglec-14 (activating) have been shown to have recipr...

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Bibliographic Details
Main Authors: Chih-Ming Tsai, Angelica M. Riestra, Syed Raza Ali, Jerry J. Fong, Janet Z. Liu, Gillian Hughes, Ajit Varki, Victor Nizet
Format: Article
Language:English
Published: Karger Publishers 2019-12-01
Series:Journal of Innate Immunity
Subjects:
siglec
interleukin-1β
caspase-1
inflammasome
macrophages
innate immunity
vimentin
Online Access:https://www.karger.com/Article/FullText/504323

Internet

https://www.karger.com/Article/FullText/504323

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