NSG-Mice Reveal the Importance of a Functional Innate and Adaptive Immune Response to Overcome RVFV Infection

NSG-Mice Reveal the Importance of a Functional Innate and Adaptive Immune Response to Overcome RVFV Infection

Rift Valley fever (RVF) is a zoonotic disease caused by RVF Phlebovirus (RVFV). The RVFV MP-12 vaccine strain is known to exhibit residual virulence in the case of a deficient interferon type 1 response. The hypothesis of this study is that virus replication and severity of lesions induced by the MP...

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Bibliographic Details
Main Authors: Lukas Mathias Michaely, Melanie Rissmann, Markus Keller, Rebecca König, Felicitas von Arnim, Martin Eiden, Karl Rohn, Wolfgang Baumgärtner, Martin Groschup, Reiner Ulrich
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Viruses
Subjects:
Rift Valley fever
immunodeficiency
innate immunity
adaptive immunity
virus persistence
Online Access:https://www.mdpi.com/1999-4915/14/2/350

Internet

https://www.mdpi.com/1999-4915/14/2/350

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