RNAi-dependent and independent control of LINE1 accumulation and mobility in mouse embryonic stem cells.

RNAi-dependent and independent control of LINE1 accumulation and mobility in mouse embryonic stem cells.

In most mouse tissues, long-interspersed elements-1 (L1s) are silenced via methylation of their 5'-untranslated regions (5'-UTR). A gradual loss-of-methylation in pre-implantation embryos coincides with L1 retrotransposition in blastocysts, generating potentially harmful mutations. Here, w...

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Bibliographic Details
Main Authors: Constance Ciaudo, Florence Jay, Ikuhiro Okamoto, Chong-Jian Chen, Alexis Sarazin, Nicolas Servant, Emmanuel Barillot, Edith Heard, Olivier Voinnet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-11-01
Series:PLoS Genetics
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24244175/pdf/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24244175/pdf/?tool=EBI

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