Cyclodextrin–polysaccharide-based, in situ-gelled system for ocular antifungal delivery
Fluconazole was studied with two different hydrophilic cyclodextrins (hydroxypropyl-β-cyclodextrin (HPBCD) and sulfobutyl ether-β-cyclodextrin (SBECD)) for the formation of inclusion complexes. HPBCD and SBECD showed low cell cytotoxicity in human keratocytes as assessed by the label-free xCELLigenc...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Beilstein-Institut
2014-12-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.10.308 |
| _version_ | 1828965510088228864 |
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| author | Anxo Fernández-Ferreiro Noelia Fernández Bargiela María Santiago Varela Maria Gil Martínez Maria Pardo Antonio Piñeiro Ces José Blanco Méndez Miguel González Barcia Maria Jesus Lamas Francisco.J. Otero-Espinar |
| author_facet | Anxo Fernández-Ferreiro Noelia Fernández Bargiela María Santiago Varela Maria Gil Martínez Maria Pardo Antonio Piñeiro Ces José Blanco Méndez Miguel González Barcia Maria Jesus Lamas Francisco.J. Otero-Espinar |
| author_sort | Anxo Fernández-Ferreiro |
| collection | DOAJ |
| description | Fluconazole was studied with two different hydrophilic cyclodextrins (hydroxypropyl-β-cyclodextrin (HPBCD) and sulfobutyl ether-β-cyclodextrin (SBECD)) for the formation of inclusion complexes. HPBCD and SBECD showed low cell cytotoxicity in human keratocytes as assessed by the label-free xCELLigence system for real-time monitoring. The fluconazole–HPBCD complex was incorporated into an ion-sensitive ophthalmic gel composed of the natural polysaccharides gellan gum and κ-carrageenan. This system showed good bioadhesive properties and effective control of fluconazole release. |
| first_indexed | 2024-12-14T11:11:39Z |
| format | Article |
| id | doaj.art-63ec2e84223c4f9db1470695daeb1029 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-14T11:11:39Z |
| publishDate | 2014-12-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-63ec2e84223c4f9db1470695daeb10292022-12-21T23:04:14ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972014-12-011012903291110.3762/bjoc.10.3081860-5397-10-308Cyclodextrin–polysaccharide-based, in situ-gelled system for ocular antifungal deliveryAnxo Fernández-Ferreiro0Noelia Fernández Bargiela1María Santiago Varela2Maria Gil Martínez3Maria Pardo4Antonio Piñeiro Ces5José Blanco Méndez6Miguel González Barcia7Maria Jesus Lamas8Francisco.J. Otero-Espinar9Pharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Santiago de Compostela (USC), Praza Seminario de Estudos Galegos s/n, Santiago de Compostela, 1570, SpainPharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Santiago de Compostela (USC), Praza Seminario de Estudos Galegos s/n, Santiago de Compostela, 1570, SpainOphthalmology Department, Hospital de Conxo, Xerencia de Xestión Integrada de Santiago de Compostela, SERGAS, Rua Ramón Baltar s/n, Santiago de Compostela, 15706, SpainOphthalmology Department, Hospital de Conxo, Xerencia de Xestión Integrada de Santiago de Compostela, SERGAS, Rua Ramón Baltar s/n, Santiago de Compostela, 15706, SpainGrupo Obesidomica, Instituto de Investigación Sanitaria (IDIS-ISCIII), SERGAS, Travesía da Choupana s/n, Santiago de Compostela, 15706, SpainOphthalmology Department, Hospital de Conxo, Xerencia de Xestión Integrada de Santiago de Compostela, SERGAS, Rua Ramón Baltar s/n, Santiago de Compostela, 15706, SpainPharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Santiago de Compostela (USC), Praza Seminario de Estudos Galegos s/n, Santiago de Compostela, 1570, SpainPharmacy Department, Xerencia de Xestión Integrada de Santiago de Compostela, SERGAS, Travesía Choupana s/n, Santiago de Compostela, 15706, SpainPharmacy Department, Xerencia de Xestión Integrada de Santiago de Compostela, SERGAS, Travesía Choupana s/n, Santiago de Compostela, 15706, SpainPharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Santiago de Compostela (USC), Praza Seminario de Estudos Galegos s/n, Santiago de Compostela, 1570, SpainFluconazole was studied with two different hydrophilic cyclodextrins (hydroxypropyl-β-cyclodextrin (HPBCD) and sulfobutyl ether-β-cyclodextrin (SBECD)) for the formation of inclusion complexes. HPBCD and SBECD showed low cell cytotoxicity in human keratocytes as assessed by the label-free xCELLigence system for real-time monitoring. The fluconazole–HPBCD complex was incorporated into an ion-sensitive ophthalmic gel composed of the natural polysaccharides gellan gum and κ-carrageenan. This system showed good bioadhesive properties and effective control of fluconazole release.https://doi.org/10.3762/bjoc.10.308cyclodextrinseye dropsfluconazolehydroxypropyl-β-cyclodextrinsulfobutylether-β-cyclodextrin |
| spellingShingle | Anxo Fernández-Ferreiro Noelia Fernández Bargiela María Santiago Varela Maria Gil Martínez Maria Pardo Antonio Piñeiro Ces José Blanco Méndez Miguel González Barcia Maria Jesus Lamas Francisco.J. Otero-Espinar Cyclodextrin–polysaccharide-based, in situ-gelled system for ocular antifungal delivery Beilstein Journal of Organic Chemistry cyclodextrins eye drops fluconazole hydroxypropyl-β-cyclodextrin sulfobutylether-β-cyclodextrin |
| title | Cyclodextrin–polysaccharide-based, in situ-gelled system for ocular antifungal delivery |
| title_full | Cyclodextrin–polysaccharide-based, in situ-gelled system for ocular antifungal delivery |
| title_fullStr | Cyclodextrin–polysaccharide-based, in situ-gelled system for ocular antifungal delivery |
| title_full_unstemmed | Cyclodextrin–polysaccharide-based, in situ-gelled system for ocular antifungal delivery |
| title_short | Cyclodextrin–polysaccharide-based, in situ-gelled system for ocular antifungal delivery |
| title_sort | cyclodextrin polysaccharide based in situ gelled system for ocular antifungal delivery |
| topic | cyclodextrins eye drops fluconazole hydroxypropyl-β-cyclodextrin sulfobutylether-β-cyclodextrin |
| url | https://doi.org/10.3762/bjoc.10.308 |
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