The Extracellular Matrix in Pancreatic Cancer: Description of a Complex Network and Promising Therapeutic Options

The Extracellular Matrix in Pancreatic Cancer: Description of a Complex Network and Promising Therapeutic Options

The stroma is a relevant player in driving and supporting the progression of pancreatic ductal adenocarcinoma (PDAC), and a large body of evidence highlights its role in hindering the efficacy of current therapies. In fact, the dense extracellular matrix (ECM) characterizing this tumor acts as a nat...

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Bibliographic Details
Main Authors: Benedetta Ferrara, Cataldo Pignatelli, Mélissande Cossutta, Antonio Citro, José Courty, Lorenzo Piemonti
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
extracellular matrix
stroma
stiffness
solid stress
matrix remodeling
cancer-associated fibroblasts
Online Access:https://www.mdpi.com/2072-6694/13/17/4442

Internet

https://www.mdpi.com/2072-6694/13/17/4442

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