Nonsequential Splicing Events Alter Antisense-Mediated Exon Skipping Outcome in <i>COL7A1</i>

Nonsequential Splicing Events Alter Antisense-Mediated Exon Skipping Outcome in <i>COL7A1</i>

The <i>COL7A1</i> gene encodes homotrimer fibrils essential for anchoring dermal and epidermal layers, and pathogenic mutations in <i>COL7A1</i> can cause recessive or dominant dystrophic epidermolysis bullosa. As a monogenic disease gene, <i>COL7A1</i> constitute...

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Bibliographic Details
Main Authors: Kristin A. Ham, May Thandar Aung-Htut, Sue Fletcher, Steve D. Wilton
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
<i>COL7A1</i>
dystrophic epidermolysis bullosa
antisense oligonucleotides
splice-switching
exon skipping
intron retention
Online Access:https://www.mdpi.com/1422-0067/21/20/7705

Internet

https://www.mdpi.com/1422-0067/21/20/7705

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