HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin (LtxA).

HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin (LtxA).

The cellular adhesion molecule LFA-1 and its ICAM-1 ligand play an important role in promoting HIV-1 infectivity and transmission. These molecules are present on the envelope of HIV-1 virions and are integral components of the HIV virological synapse. However, cellular activation is required to conv...

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Bibliographic Details
Main Authors: Catarina E Hioe, Michael Tuen, Gaia Vasiliver-Shamis, Yelina Alvarez, Kathleen C Prins, Sagarika Banerjee, Arthur Nádas, Michael W Cho, Michael L Dustin, Scott C Kachlany
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3151267?pdf=render

Internet

http://europepmc.org/articles/PMC3151267?pdf=render

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