Inflammatory Bowel Disease-Associated Gut Commensals Degrade Components of the Extracellular Matrix

Inflammatory Bowel Disease-Associated Gut Commensals Degrade Components of the Extracellular Matrix

ABSTRACT Extracellular matrix (ECM) remodeling has emerged as a key feature of inflammatory bowel disease (IBD), and ECM fragments have been proposed as markers of clinical disease severity. Recent studies report increased protease activity in the gut microbiota of IBD patients. Nonetheless, the rel...

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Bibliographic Details
Main Authors: Ana Maria Porras, Hao Zhou, Qiaojuan Shi, Xieyue Xiao, Randy Longman, Ilana Lauren Brito
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:mBio
Subjects:
gut microbiome
inflammatory bowel disease
extracellular matrix
host-microbe interactions
colitis
proteases
Online Access:https://journals.asm.org/doi/10.1128/mbio.02201-22

Internet

https://journals.asm.org/doi/10.1128/mbio.02201-22

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