Epigenetic mechanisms underlying subtype heterogeneity and tumor recurrence in prostate cancer

Prostate cancer is a highly heterogeneous disease. Progression on androgen deprivation therapy (ADT) to castration-resistant (CRPC), or neuroendocrine prostate cancer (NEPC), is associated with poor patient survival. This comment highlights recent evidence on the epigenetic mechanisms underlying the...

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Bibliographic Details
Main Authors: Goutam Chakraborty, Kasmira Gupta, Natasha Kyprianou
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36253-1