Targeted degradation of ⍺-synuclein aggregates in Parkinson’s disease using the AUTOTAC technology

Targeted degradation of ⍺-synuclein aggregates in Parkinson’s disease using the AUTOTAC technology

Abstract Background There are currently no disease-modifying therapeutics for Parkinson’s disease (PD). Although extensive efforts were undertaken to develop therapeutic approaches to delay the symptoms of PD, untreated α-synuclein (α-syn) aggregates cause cellular toxicity and stimulate further dis...

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Main Authors: Jihoon Lee, Ki Woon Sung, Eun-Jin Bae, Dabin Yoon, Dasarang Kim, Jin Saem Lee, Da-ha Park, Daniel Youngjae Park, Su Ran Mun, Soon Chul Kwon, Hye Yeon Kim, Joo-Ok Min, Seung-Jae Lee, Young Ho Suh, Yong Tae Kwon
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Molecular Neurodegeneration
Subjects:
The autophagy-lysosome system
The N-degron pathway
p62/SQSTM1/Sequestosome-1
Macroautophagy
Lysosome
Targeted protein degradation
Online Access:https://doi.org/10.1186/s13024-023-00630-7

Internet

https://doi.org/10.1186/s13024-023-00630-7

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