Inflammation-induced hypoparathyroidism triggered by combination immune checkpoint blockade for melanoma

Abstract Background Treatment with a combination of PD-1 and CTLA-4 targeted checkpoint inhibition has improved outcome of melanoma patients and led to durable remissions but is also associated with significant toxicities. Endocrinopathies such as thyroiditis and hypophysitis are often seen, but oth...

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Bibliographic Details
Main Authors: Beckey Trinh, Guacimara Ortega Sanchez, Petra Herzig, Heinz Läubli
Format: Article
Language:English
Published: BMJ Publishing Group 2019-02-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Online Access:http://link.springer.com/article/10.1186/s40425-019-0528-x