Design and Stereochemical Research (DFT, ECD and Crystal Structure) of Novel Bedaquiline Analogs as Potent Antituberculosis Agents

Design and Stereochemical Research (DFT, ECD and Crystal Structure) of Novel Bedaquiline Analogs as Potent Antituberculosis Agents

A series of bedaquiline analogs containing H-bond donors were designed as anti-Mycobacterium tuberculosis drugs. A pair of diastereoisomers (R/S- and S/S-isomers) was selected from these designed compounds for synthetic and stereochemical research. The title compounds were synthesized from chiral pr...

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Bibliographic Details
Main Authors: Yiding Geng, Linwei Li, Chengjun Wu, Yumeng Chi, Zhen Li, Wei Xu, Tiemin Sun
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Molecules
Subjects:
anti-tuberculosis
absolute configuration
DFT
ECD
X-ray diffraction
docking
Online Access:http://www.mdpi.com/1420-3049/21/7/875

Internet

http://www.mdpi.com/1420-3049/21/7/875

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