Targeting NF-κB signaling cascades of glioblastoma by a natural benzophenone, garcinol, via in vitro and molecular docking approaches

Targeting NF-κB signaling cascades of glioblastoma by a natural benzophenone, garcinol, via in vitro and molecular docking approaches

Glioblastoma multiforme (GBM) is regarded as the most aggressive form of brain tumor delineated by high cellular heterogeneity; it is resistant to conventional therapeutic regimens. In this study, the anti-cancer potential of garcinol, a naturally derived benzophenone, was assessed against GBM. Duri...

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Bibliographic Details
Main Authors: Syed Mohd Danish Rizvi, Ibrahim A. Almazni, Mamdoh S. Moawadh, Zeyad M. Alharbi, Nawal Helmi, Leena S. Alqahtani, Talib Hussain, Ahmed Alafnan, Afrasim Moin, AbdElmoneim O. Elkhalifa, Amir Mahgoub Awadelkareem, Mohammad Khalid, Rohit Kumar Tiwari
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Chemistry
Subjects:
anti-cancer
benzophenone
garcinol
glioblastoma multiforme
NF-κB
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2024.1352009/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2024.1352009/full

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