Sirtuin 3 Deficiency Accelerates Hypertensive Cardiac Remodeling by Impairing Angiogenesis

Sirtuin 3 Deficiency Accelerates Hypertensive Cardiac Remodeling by Impairing Angiogenesis

BackgroundEmerging evidence indicates that impaired angiogenesis may contribute to hypertension‐induced cardiac remodeling. The nicotinamide adenine dinucleotide–dependent deacetylase Sirtuin 3 (SIRT3) has the potential to modulate angiogenesis, but this has not been confirmed. As such, the aim of t...

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Bibliographic Details
Main Authors: Tong Wei, Gaojian Huang, Jing Gao, Chenglin Huang, Mengwei Sun, Jian Wu, Juan Bu, Weili Shen
Format: Article
Language:English
Published: Wiley 2017-08-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
angiogenesis
cardiac remodeling
mitochondria
mitophagy
oxidative stress
Sirtuin 3
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.117.006114

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.117.006114

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