BCL11B is positioned upstream of PLZF and RORγt to control thymic development of mucosal-associated invariant T cells and MAIT17 program

BCL11B is positioned upstream of PLZF and RORγt to control thymic development of mucosal-associated invariant T cells and MAIT17 program

Summary: Mucosal-associated invariant T (MAIT) cells recognize microbial riboflavin metabolites presented by MR1 and play role in immune responses to microbial infections and tumors. We report here that absence of the transcription factor (TF) Bcl11b in mice alters predominantly MAIT17 cells in the...

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Bibliographic Details
Main Authors: Theodore T. Drashansky, Eric Y. Helm, Nina Curkovic, Jaimee Cooper, Pingyan Cheng, Xianghong Chen, Namrata Gautam, Lingsong Meng, Alexander J. Kwiatkowski, William O. Collins, Benjamin G. Keselowsky, Derek Sant’Angelo, Zhiguang Huo, Weizhou Zhang, Liang Zhou, Dorina Avram
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:iScience
Subjects:
Immunology
Systems Biology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221002753

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http://www.sciencedirect.com/science/article/pii/S2589004221002753

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