COVID-19 patients display changes in lymphocyte subsets with a higher frequency of dysfunctional CD8lo T cells associated with disease severity

COVID-19 patients display changes in lymphocyte subsets with a higher frequency of dysfunctional CD8lo T cells associated with disease severity

This work examines cellular immunity against SARS-CoV-2 in patients from Córdoba, Argentina, during two major waves characterized by different circulating viral variants and different social behavior. Using flow cytometry, we evaluated the main lymphocyte populations of peripheral blood from hospita...

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Bibliographic Details
Main Authors: Luisina Ines Onofrio, Constanza Marin, Jeremías Dutto, María Belén Brugo, Ruth Eliana Baigorri, Sabrina Noemi Bossio, Juan Nahuel Quiróz, Laura Almada, Federico Ruiz Moreno, Carolina Olivera, Silene M. Silvera-Ruiz, Nicolás Eric Ponce, Paula Alejandra Icely, María Carolina Amezcua Vesely, Laura Fozzatti, María Cecilia Rodríguez-Galán, Cinthia Carolina Stempin, Laura Cervi, ImmunoCovid-CBA, Belkys Angélica Maletto, Eva Virginia Acosta Rodríguez, Mariana Bertone, Claudio Daniel Abiega, Daiana Escudero, Adrián Kahn, Juan Pablo Caeiro, Mariana Maccioni, Claudia Cristina Motrán, Adriana Gruppi, Claudia Elena Sotomayor, Laura Silvina Chiapello, Carolina Lucia Montes, Fabio Cerban, Pablo Iribarren, Daniela Soledad Arroyo, Gabriel Moron
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
COVID-19
SARS-CoV-2
cytotoxic CD4 + T cells
CD8 + T cells
T cells dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1223730/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1223730/full

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