shRNA-mediated gene silencing of HDAC11 empowers CAR-T cells against prostate cancer

Epigenetic mechanisms are involved in several cellular functions, and their role in the immune system is of prime importance. Histone deacetylases (HDACs) are an important set of enzymes that regulate and catalyze the deacetylation process. HDACs have been proven beneficial targets for improving the...

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Bibliographic Details
Main Authors: Hongmei Zhang, Jie Yao, Iqra Ajmal, Muhammad Asad Farooq, Wenzheng Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1369406/full