Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis via Regulating the MAPK/NF-κB-Autophagy Pathway

Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis via Regulating the MAPK/NF-κB-Autophagy Pathway

Osteoarthritis is a worldwide joint disease caused by abnormal chondrocytic metabolism. However, traditional therapeutic methods aimed at anti-inflammation for early-stage disease are palliative. In the present study, we demonstrated that cepharanthine (CEP), extracted from the plant Stephania cepha...

Full description

Bibliographic Details
Main Authors: Minjun Yao, Caihua Zhang, Lingzhi Ni, Xiaoxiao Ji, Jianqiao Hong, Yazhou Chen, Jie Wang, Congsun Li, Jiyan Lin, Tingting Lu, Yihao Sheng, Menghao Sun, Mingmin Shi, Chenhe Zhou, Xunzi Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
cepharanthine
chondrocytes
osteoarthritis
MAPK
NF-κB
autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.854239/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.854239/full

Similar Items