The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses

The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses

Rac GTPases are required for neutrophil adhesion and migration, and for the neutrophil effector responses that kill pathogens. These Rac-dependent functions are impaired when neutrophils lack the activators of Rac, Rac-GEFs from the Prex, Vav, and Dock families. In this study, we demonstrate that Ti...

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Bibliographic Details
Main Authors: Kirsti Hornigold, Martin J. Baker, Polly A. Machin, Stephen A. Chetwynd, Anna-Karin Johnsson, Chiara Pantarelli, Priota Islam, Melanie Stammers, Laraine Crossland, David Oxley, Hanneke Okkenhaug, Simon Walker, Rachael Walker, Anne Segonds-Pichon, Yoshinori Fukui, Angeliki Malliri, Heidi C. E. Welch
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
Tiam1
Rac
neutrophils
Rac-GEF
small GTPase
Prex1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1223653/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1223653/full

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