Dexamethasone-Loaded Radially Mesoporous Silica Nanoparticles for Sustained Anti-Inflammatory Effects in Rheumatoid Arthritis
Radially mesoporous silica nanoparticles (RMSNs) with protonated amine functionality are proposed to be a dexamethasone (Dex) carrier that could achieve a sustained anti-inflammatory effect in rheumatoid arthritis (RA). High-capacity loading and a sustained release of target drugs were achieved by r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/5/985 |
| _version_ | 1797496713877913600 |
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| author | Sang Jun Kim Youngbo Choi Khee Tae Min Surin Hong |
| author_facet | Sang Jun Kim Youngbo Choi Khee Tae Min Surin Hong |
| author_sort | Sang Jun Kim |
| collection | DOAJ |
| description | Radially mesoporous silica nanoparticles (RMSNs) with protonated amine functionality are proposed to be a dexamethasone (Dex) carrier that could achieve a sustained anti-inflammatory effect in rheumatoid arthritis (RA). High-capacity loading and a sustained release of target drugs were achieved by radially oriented mesopores and surface functionality. The maximum loading efficiency was confirmed to be about 76 wt%, which is about two times greater than that of representative mesopores silica, SBA-15. In addition, Dex-loaded RMSNs allow a sustained-release profile with about 92% of the loaded Dex for 100 h in vitro, resulting in 2.3-fold better delivery efficiency of Dex than that of the SBA-15 over the same period. In vivo evaluation of the inhibitory effects on inflammation in a RA disease rat model showed that, compared with the control groups, the group treated with Dex-loaded RMSNs sustained significant anti-inflammatory effects and recovery of cartilage over a period of 8 weeks. The in vivo effects were confirmed via micro-computed tomography, bone mineral density measurements, and modified Mankin scoring. The proposed Dex-loaded RMSNs prolonged the life of the in vivo concentrations of therapeutic agents and maximized their effect, which should encourage its application. |
| first_indexed | 2024-03-10T03:07:31Z |
| format | Article |
| id | doaj.art-640088273f46448bbab7e4fc6009d05d |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T03:07:31Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
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| series | Pharmaceutics |
| spelling | doaj.art-640088273f46448bbab7e4fc6009d05d2023-11-23T12:37:40ZengMDPI AGPharmaceutics1999-49232022-05-0114598510.3390/pharmaceutics14050985Dexamethasone-Loaded Radially Mesoporous Silica Nanoparticles for Sustained Anti-Inflammatory Effects in Rheumatoid ArthritisSang Jun Kim0Youngbo Choi1Khee Tae Min2Surin Hong3Seoul Jun Research Center, Seoul Jun Rehabilitation Clinic, Seoul 06737, KoreaDepartment of Safety Engineering, Chungbuk National University, Gyeongju 28644, KoreaDepartment of Biotechnology, CHA University, Seongnam 13488, KoreaDepartment of Biotechnology, CHA University, Seongnam 13488, KoreaRadially mesoporous silica nanoparticles (RMSNs) with protonated amine functionality are proposed to be a dexamethasone (Dex) carrier that could achieve a sustained anti-inflammatory effect in rheumatoid arthritis (RA). High-capacity loading and a sustained release of target drugs were achieved by radially oriented mesopores and surface functionality. The maximum loading efficiency was confirmed to be about 76 wt%, which is about two times greater than that of representative mesopores silica, SBA-15. In addition, Dex-loaded RMSNs allow a sustained-release profile with about 92% of the loaded Dex for 100 h in vitro, resulting in 2.3-fold better delivery efficiency of Dex than that of the SBA-15 over the same period. In vivo evaluation of the inhibitory effects on inflammation in a RA disease rat model showed that, compared with the control groups, the group treated with Dex-loaded RMSNs sustained significant anti-inflammatory effects and recovery of cartilage over a period of 8 weeks. The in vivo effects were confirmed via micro-computed tomography, bone mineral density measurements, and modified Mankin scoring. The proposed Dex-loaded RMSNs prolonged the life of the in vivo concentrations of therapeutic agents and maximized their effect, which should encourage its application.https://www.mdpi.com/1999-4923/14/5/985anti-inflammatorydrug deliveryloading efficiencyrheumatoid arthritissilica nanoparticlessustained release |
| spellingShingle | Sang Jun Kim Youngbo Choi Khee Tae Min Surin Hong Dexamethasone-Loaded Radially Mesoporous Silica Nanoparticles for Sustained Anti-Inflammatory Effects in Rheumatoid Arthritis Pharmaceutics anti-inflammatory drug delivery loading efficiency rheumatoid arthritis silica nanoparticles sustained release |
| title | Dexamethasone-Loaded Radially Mesoporous Silica Nanoparticles for Sustained Anti-Inflammatory Effects in Rheumatoid Arthritis |
| title_full | Dexamethasone-Loaded Radially Mesoporous Silica Nanoparticles for Sustained Anti-Inflammatory Effects in Rheumatoid Arthritis |
| title_fullStr | Dexamethasone-Loaded Radially Mesoporous Silica Nanoparticles for Sustained Anti-Inflammatory Effects in Rheumatoid Arthritis |
| title_full_unstemmed | Dexamethasone-Loaded Radially Mesoporous Silica Nanoparticles for Sustained Anti-Inflammatory Effects in Rheumatoid Arthritis |
| title_short | Dexamethasone-Loaded Radially Mesoporous Silica Nanoparticles for Sustained Anti-Inflammatory Effects in Rheumatoid Arthritis |
| title_sort | dexamethasone loaded radially mesoporous silica nanoparticles for sustained anti inflammatory effects in rheumatoid arthritis |
| topic | anti-inflammatory drug delivery loading efficiency rheumatoid arthritis silica nanoparticles sustained release |
| url | https://www.mdpi.com/1999-4923/14/5/985 |
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