Dickkopf-Related Protein 2 is Epigenetically Inactivated and Suppresses Colorectal Cancer Growth and Tumor Metastasis by Antagonizing Wnt/β-Catenin Signaling

Dickkopf-Related Protein 2 is Epigenetically Inactivated and Suppresses Colorectal Cancer Growth and Tumor Metastasis by Antagonizing Wnt/β-Catenin Signaling

Background/Aims: Aberrant activation of the Wnt/β-catenin signaling pathway plays a key role in the pathogenesis of multiple tumors including digestive cancers. Recent studies have reported that Dickkopf-related protein 2 (DKK2) is epigenetically inactivated in numerous types of cancers and that its...

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Bibliographic Details
Main Authors: Can Wang, Yujuan Yue, Bianfei Shao, Zhu Qiu, Junhao Mu, Jun Tang, Xiaofan Han, Tingxiu Xiang, Guosheng Ren
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
DKK2
Colon cancer
Tumor suppressor
Methylation
Wnt/β-catenin
Online Access:http://www.karger.com/Article/FullText/471861

Internet

http://www.karger.com/Article/FullText/471861

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