Tailoring Apixaban in Nanostructured Lipid Carrier Enhancing Its Oral Bioavailability and Anticoagulant Activity

Tailoring Apixaban in Nanostructured Lipid Carrier Enhancing Its Oral Bioavailability and Anticoagulant Activity

Apixaban (Apx), an oral anticoagulant drug, is a direct factor Xa inhibitor for the prophylaxis against venous thromboembolism. Apx has limited oral bioavailability and poor water solubility. The goal of this study was to improve the formulation of an Apx-loaded nanostructured lipid carrier (NLC) to...

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Bibliographic Details
Main Authors: Mohamed F. Zaky, Mohamed A. Megahed, Taha M. Hammady, Shadeed Gad, Mamdouh Mostafa Ghorab, Khalid M. El-Say
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
apixaban
venous thromboembolism
nanostructured lipid carrier
box–behnken design
industrial development
in vivo pharmacokinetic
Online Access:https://www.mdpi.com/1999-4923/15/1/80

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https://www.mdpi.com/1999-4923/15/1/80

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