Role of Stereochemistry on the Biological Activity of Nature-Inspired 3-Br-Acivicin Isomers and Derivatives

Role of Stereochemistry on the Biological Activity of Nature-Inspired 3-Br-Acivicin Isomers and Derivatives

Chiral natural compounds are often biosynthesized in an enantiomerically pure fashion, and stereochemistry plays a pivotal role in biological activity. Herein, we investigated the significance of chirality for nature-inspired 3-Br-acivicin (3-BA) and its derivatives. The three unnatural isomers of 3...

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Bibliographic Details
Main Authors: Andrea Galbiati, Aureliano Zana, Chiara Borsari, Marco Persico, Stefania Bova, Oleh Tkachuk, Alexandra Ioana Corfu, Lucia Tamborini, Nicoletta Basilico, Caterina Fattorusso, Stefano Bruno, Silvia Parapini, Paola Conti
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Molecules
Subjects:
stereochemistry
3-Br-acivicin
<i>Plasmodium falciparum</i>
glyceraldehyde 3-phosphate dehydrogenase
multitarget
covalent inhibitors
Online Access:https://www.mdpi.com/1420-3049/28/7/3172

Internet

https://www.mdpi.com/1420-3049/28/7/3172

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