LncRNA KCNQ1OT1 Secreted by Tumor Cell-Derived Exosomes Mediates Immune Escape in Colorectal Cancer by Regulating PD-L1 Ubiquitination via MiR-30a-5p/USP22

LncRNA KCNQ1OT1 Secreted by Tumor Cell-Derived Exosomes Mediates Immune Escape in Colorectal Cancer by Regulating PD-L1 Ubiquitination via MiR-30a-5p/USP22

Background: This study tried to explore the mechanism of long non-coding RNA (lncRNA) KCNQ1OT1 in tumor immune escape.Methods: Gene Expression Omnibus (GEO) and microarray analysis were used to screen the differentially expressed lncRNA and microRNA (miRNA) in normal tissues and tumor tissues. Quant...

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Bibliographic Details
Main Authors: Di Xian, Liangbo Niu, Jie Zeng, Lei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
colorectal cancer
lncRNA KCNQ1OT1
PD-L1
immune escape
exosomes
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.653808/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.653808/full

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