DNA-PKcs restricts Zika virus spreading and is required for effective antiviral response

DNA-PKcs restricts Zika virus spreading and is required for effective antiviral response

Zika virus (ZIKV) is a single-strand RNA mosquito-borne flavivirus with significant public health impact. ZIKV infection induces double-strand DNA breaks (DSBs) in human neural progenitor cells that may contribute to severe neuronal manifestations in newborns. The DNA-PK complex plays a critical rol...

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Bibliographic Details
Main Authors: Daniel de Oliveira Patricio, Greicy Brisa Malaquias Dias, Lucilene Wildner Granella, Ben Trigg, Helena Claire Teague, Dina Bittencourt, André Báfica, Alfeu Zanotto-Filho, Brian Ferguson, Daniel Santos Mansur
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
Zika virus
interferon
DNA-PKcs
double-strand DNA breaks
infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1042463/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1042463/full

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