DNA-PKcs restricts Zika virus spreading and is required for effective antiviral response

DNA-PKcs restricts Zika virus spreading and is required for effective antiviral response

Zika virus (ZIKV) is a single-strand RNA mosquito-borne flavivirus with significant public health impact. ZIKV infection induces double-strand DNA breaks (DSBs) in human neural progenitor cells that may contribute to severe neuronal manifestations in newborns. The DNA-PK complex plays a critical rol...

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Bibliographic Details
Main Authors:	Daniel de Oliveira Patricio, Greicy Brisa Malaquias Dias, Lucilene Wildner Granella, Ben Trigg, Helena Claire Teague, Dina Bittencourt, André Báfica, Alfeu Zanotto-Filho, Brian Ferguson, Daniel Santos Mansur
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Series:	Frontiers in Immunology
Subjects:	Zika virus interferon DNA-PKcs double-strand DNA breaks infection
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1042463/full

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