Mechanical-Stress-Related Epigenetic Regulation of <i>ZIC1</i> Transcription Factor in the Etiology of Postmenopausal Osteoporosis

Mechanical-Stress-Related Epigenetic Regulation of <i>ZIC1</i> Transcription Factor in the Etiology of Postmenopausal Osteoporosis

Mechanical loading exerts a profound influence on bone density and architecture, but the exact mechanism is unknown. Our study shows that expression of the neurological transcriptional factor zinc finger of the cerebellum 1 (<i>ZIC1</i>) is markedly increased in trabecular bone biopsies...

Full description

Bibliographic Details
Main Authors: Harish K. Datta, Marianne K. Kringen, Stephen P. Tuck, Georgia Salpingidou, Ole K. Olstad, Kaare M. Gautvik, Simon J. Cockell, Vigdis T. Gautvik, Michael Prediger, Jun Jie Wu, Mark A. Birch, Sjur Reppe
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
osteoporosis
bone
mechanical stress
epigenetic
<i>ZIC1</i> transcription factor
Online Access:https://www.mdpi.com/1422-0067/23/6/2957

Internet

https://www.mdpi.com/1422-0067/23/6/2957

Similar Items