Induction of reactive oxygen species by mechanical stretch drives endothelin production in neonatal pig renal epithelial cells

Induction of reactive oxygen species by mechanical stretch drives endothelin production in neonatal pig renal epithelial cells

Vasoactive endothelin (ET) is generated by ET converting enzyme (ECE)-induced proteolytic processing of pro-molecule big ET to biologically active peptides. H2O2 has been shown to increase the expression of ECE1 via transactivation of its promoter. The present study demonstrates that H2O2 triggered...

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Bibliographic Details
Main Authors: Ravi Kumar, Hitesh Soni, Jeremiah M. Afolabi, Praghalathan Kanthakumar, Pratheesh D. Mankuzhy, Samson A. Iwhiwhu, Adebowale Adebiyi
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Redox Biology
Subjects:
Mechanical stretch
Urinary tract obstruction
Hydrogen peroxide
Endothelin converting enzyme
Endothelin
Acute kidney injury
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722001665

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http://www.sciencedirect.com/science/article/pii/S2213231722001665

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