Polyphenol-rich jaboticaba (Myrciaria jaboticaba) peel and seed powder induces browning of subcutaneous white adipose tissue and improves metabolic status in high-fat-fed mice
In the present study, we investigated the effects of polyphenol-rich jaboticaba peel and seed powder (JPSP) supplementation for four weeks in a concentration-dependent manner (5 %, 10 %, and 15 %) in the adipose tissue and the metabolic status of diet-induced obese mice. JPSP prevents weight gain an...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622003085 |
| _version_ | 1811265014421520384 |
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| author | Patricia Leticia Trindade Fabiane Ferreira Martins Elaine dos Ramos Soares Elisa Monteiro Bernardes Francisco Vardiero Angela de Castro Resende Vanessa Souza-Mello Julio Beltrame Daleprane |
| author_facet | Patricia Leticia Trindade Fabiane Ferreira Martins Elaine dos Ramos Soares Elisa Monteiro Bernardes Francisco Vardiero Angela de Castro Resende Vanessa Souza-Mello Julio Beltrame Daleprane |
| author_sort | Patricia Leticia Trindade |
| collection | DOAJ |
| description | In the present study, we investigated the effects of polyphenol-rich jaboticaba peel and seed powder (JPSP) supplementation for four weeks in a concentration-dependent manner (5 %, 10 %, and 15 %) in the adipose tissue and the metabolic status of diet-induced obese mice. JPSP prevents weight gain and adiposity induced by HF diet consumption, reduced plasma leptin concentration, improved insulin sensitivity, and also leads to recovery of brown adipose tissue (BAT) function with increased gene expression levels of UCP1, PPAR-γ, and PGC1-α expression. JPSP consumption promoted browning in subcutaneous with adipose tissue (sWAT) observed with the appearance of specific transcription factors like UCP-1, PRDM16, and ABRB3 in groups supplemented with 10 % and 15 % of JPSP. Thus, these findings indicate that JPSP supplementation could lead to attenuation of obesity complications promoting browning in sWAT and may recovery/improve BAT function, and may be a promising strategy to lessen adiposity and/or improve obesity-mediated metabolic complications. |
| first_indexed | 2024-04-12T20:14:59Z |
| format | Article |
| id | doaj.art-6411e5a2a47447cf8280ee8e8736ffd4 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-12T20:14:59Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-6411e5a2a47447cf8280ee8e8736ffd42022-12-22T03:18:09ZengElsevierJournal of Functional Foods1756-46462022-10-0197105238Polyphenol-rich jaboticaba (Myrciaria jaboticaba) peel and seed powder induces browning of subcutaneous white adipose tissue and improves metabolic status in high-fat-fed micePatricia Leticia Trindade0Fabiane Ferreira Martins1Elaine dos Ramos Soares2Elisa Monteiro Bernardes3Francisco Vardiero4Angela de Castro Resende5Vanessa Souza-Mello6Julio Beltrame Daleprane7Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rua São Francisco Xavier, 524, 112.150 bloco F, 20550-900 Rio de Janeiro, BrazilLaboratory of Morphometry and Cardiovascular Metabolism, Department of Anatomy, LMMC, Rio de Janeiro State University, Av 28 de Setembro, 87 fds, 20551-030 Rio de Janeiro, BrazilLaboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rua São Francisco Xavier, 524, 112.150 bloco F, 20550-900 Rio de Janeiro, BrazilLaboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rua São Francisco Xavier, 524, 112.150 bloco F, 20550-900 Rio de Janeiro, BrazilLaboratory of Endothelial Cell Biology and Angiogenesis, LabAngio, Roberto Alcantara Gomes Biology Institute, Rio de Janeiro State University, Av 28 de Setembro, 87 fds, 20551-030 Rio de Janeiro, BrazilLaboratory of Cardiovascular Pharmacology and Medicinal Plants, Department of Pharmacology, Rio de Janeiro State University, Rio de Janeiro, BrazilLaboratory of Morphometry and Cardiovascular Metabolism, Department of Anatomy, LMMC, Rio de Janeiro State University, Av 28 de Setembro, 87 fds, 20551-030 Rio de Janeiro, BrazilLaboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rua São Francisco Xavier, 524, 112.150 bloco F, 20550-900 Rio de Janeiro, Brazil; Corresponding author.In the present study, we investigated the effects of polyphenol-rich jaboticaba peel and seed powder (JPSP) supplementation for four weeks in a concentration-dependent manner (5 %, 10 %, and 15 %) in the adipose tissue and the metabolic status of diet-induced obese mice. JPSP prevents weight gain and adiposity induced by HF diet consumption, reduced plasma leptin concentration, improved insulin sensitivity, and also leads to recovery of brown adipose tissue (BAT) function with increased gene expression levels of UCP1, PPAR-γ, and PGC1-α expression. JPSP consumption promoted browning in subcutaneous with adipose tissue (sWAT) observed with the appearance of specific transcription factors like UCP-1, PRDM16, and ABRB3 in groups supplemented with 10 % and 15 % of JPSP. Thus, these findings indicate that JPSP supplementation could lead to attenuation of obesity complications promoting browning in sWAT and may recovery/improve BAT function, and may be a promising strategy to lessen adiposity and/or improve obesity-mediated metabolic complications.http://www.sciencedirect.com/science/article/pii/S1756464622003085ObesityAdipose tissueBerriesJaboticabaPolyphenolsBrowning |
| spellingShingle | Patricia Leticia Trindade Fabiane Ferreira Martins Elaine dos Ramos Soares Elisa Monteiro Bernardes Francisco Vardiero Angela de Castro Resende Vanessa Souza-Mello Julio Beltrame Daleprane Polyphenol-rich jaboticaba (Myrciaria jaboticaba) peel and seed powder induces browning of subcutaneous white adipose tissue and improves metabolic status in high-fat-fed mice Journal of Functional Foods Obesity Adipose tissue Berries Jaboticaba Polyphenols Browning |
| title | Polyphenol-rich jaboticaba (Myrciaria jaboticaba) peel and seed powder induces browning of subcutaneous white adipose tissue and improves metabolic status in high-fat-fed mice |
| title_full | Polyphenol-rich jaboticaba (Myrciaria jaboticaba) peel and seed powder induces browning of subcutaneous white adipose tissue and improves metabolic status in high-fat-fed mice |
| title_fullStr | Polyphenol-rich jaboticaba (Myrciaria jaboticaba) peel and seed powder induces browning of subcutaneous white adipose tissue and improves metabolic status in high-fat-fed mice |
| title_full_unstemmed | Polyphenol-rich jaboticaba (Myrciaria jaboticaba) peel and seed powder induces browning of subcutaneous white adipose tissue and improves metabolic status in high-fat-fed mice |
| title_short | Polyphenol-rich jaboticaba (Myrciaria jaboticaba) peel and seed powder induces browning of subcutaneous white adipose tissue and improves metabolic status in high-fat-fed mice |
| title_sort | polyphenol rich jaboticaba myrciaria jaboticaba peel and seed powder induces browning of subcutaneous white adipose tissue and improves metabolic status in high fat fed mice |
| topic | Obesity Adipose tissue Berries Jaboticaba Polyphenols Browning |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622003085 |
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