The mitochondrial protease LONP1 maintains oocyte development and survival by suppressing nuclear translocation of AIFM1 in mammals

The mitochondrial protease LONP1 maintains oocyte development and survival by suppressing nuclear translocation of AIFM1 in mammals

Summary: Background: Oogenesis is a fundamental process of human reproduction, and mitochondria play crucial roles in oocyte competence. Mitochondrial ATP-dependent Lon protease 1 (LONP1) functions as a critical protein in maintaining mitochondrial and cellular homeostasis in somatic cells. However...

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Bibliographic Details
Main Authors: Xiaoqiang Sheng, Chuanming Liu, Guijun Yan, Guangyu Li, Jingyu Liu, Yanjun Yang, Shiyuan Li, Zhongxun Li, Jidong Zhou, Xin Zhen, Yang Zhang, Zhenyu Diao, Yali Hu, Chuanhai Fu, Bin Yao, Chaojun Li, Yu Cao, Bin Lu, Zhongzhou Yang, Yingying Qin, Haixiang Sun, Lijun Ding
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:EBioMedicine
Subjects:
Mitochondria
LONP1
AIFM1
Oocyte development
Oocyte survival
Premature ovarian insufficiency
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421005843

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http://www.sciencedirect.com/science/article/pii/S2352396421005843

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