Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15

Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15

Abstract DNA replication and repair defects or genotoxic treatments trigger interferon (IFN)-mediated inflammatory responses. However, whether and how IFN signaling in turn impacts the DNA replication process has remained elusive. Here we show that basal levels of the IFN-stimulated gene 15, ISG15,...

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Bibliographic Details
Main Authors: Ramona N. Moro, Uddipta Biswas, Suhas S. Kharat, Filip D. Duzanic, Prosun Das, Maria Stavrou, Maria C. Raso, Raimundo Freire, Arnab Ray Chaudhuri, Shyam K. Sharan, Lorenza Penengo
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41801-w

Internet

https://doi.org/10.1038/s41467-023-41801-w

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