Farnesyl diphosphate synthase regulated endothelial proliferation and autophagy during rat pulmonary arterial hypertension induced by monocrotaline

Farnesyl diphosphate synthase regulated endothelial proliferation and autophagy during rat pulmonary arterial hypertension induced by monocrotaline

Abstract Background The proliferation ability and autophagy level of pulmonary artery endothelial cells (PAECs) play an important role in promoting the development of pulmonary artery hypertension (PAH), and there is still no effective treatment for PAH. Farnesyl diphosphate synthase (FDPS) is a key...

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Bibliographic Details
Main Authors: Tingting Jin, Jiangting Lu, Qingbo Lv, Yingchao Gong, Zhaojin Feng, Hangying Ying, Meihui Wang, Guosheng Fu, Dongmei Jiang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Molecular Medicine
Subjects:
Farnesyl diphosphate synthase
Pulmonary artery hypertension
Endothelial
Proliferation
Autophagy
Ras-related C3 botulinum toxin substrate 1
Online Access:https://doi.org/10.1186/s10020-022-00511-7

Internet

https://doi.org/10.1186/s10020-022-00511-7

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