Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes

Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes

Long-term antibiotics are prescribed for a variety of medical conditions, recently including low back pain with Modic changes. The molecular impact of such treatment is unknown. We conducted longitudinal transcriptome and epigenome analyses in patients (<i>n</i> = 100) receiving amoxicil...

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Bibliographic Details
Main Authors: Maria Dehli Vigeland, Siri Tennebø Flåm, Magnus Dehli Vigeland, Ansgar Espeland, Manuela Zucknick, Monica Wigemyr, Lars Christian Haugli Bråten, Elisabeth Gjefsen, John-Anker Zwart, Kjersti Storheim, Linda Margareth Pedersen, Kaja Selmer, Benedicte Alexandra Lie, Kristina Gervin, The AIM Study Group
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Antibiotics
Subjects:
antibiotics
amoxicillin
gene expression
DNA methylation
immunoglobulin
Online Access:https://www.mdpi.com/2079-6382/12/7/1217

Internet

https://www.mdpi.com/2079-6382/12/7/1217

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