Involvement of Akt/CREB signaling pathways in the protective effect of EPA against interleukin-1β-induced cytotoxicity and BDNF down-regulation in cultured rat hippocampal neurons

Involvement of Akt/CREB signaling pathways in the protective effect of EPA against interleukin-1β-induced cytotoxicity and BDNF down-regulation in cultured rat hippocampal neurons

Abstract Background Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1β (IL-1β), and up-regulation of the expression of brain-derived neurotrophic factor (BDNF)...

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Bibliographic Details
Main Authors: YiLong Dong, KangJing Pu, WenJing Duan, HuiCheng Chen, LiXing Chen, YanMei Wang
Format: Article
Language:English
Published: BMC 2018-09-01
Series:BMC Neuroscience
Subjects:
Eicosapentaenoic acid
Brain-derived neurotrophic factor
Akt
Interleukin-1β
Online Access:http://link.springer.com/article/10.1186/s12868-018-0455-7

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http://link.springer.com/article/10.1186/s12868-018-0455-7

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