Metabolomic analysis and mass spectrometry imaging after neonatal stroke and cell therapies in mouse brains

Abstract Ischemic brain injury provokes complex, time-dependent downstream pathways that ultimately lead to cell death. We aimed to demonstrate the levels of a wide range of metabolites in brain lysates and their on-tissue distribution following neonatal stroke and cell therapies. Postnatal day 12 m...

Full description

Bibliographic Details
Main Authors: Emi Tanaka, Yuko Ogawa, Ritsuko Fujii, Tomomi Shimonaka, Yoshiaki Sato, Takashi Hamazaki, Tokiko Nagamura-Inoue, Haruo Shintaku, Masahiro Tsuji
Format: Article
Language:English
Published: Nature Portfolio 2020-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-78930-x