Ubiquitin Carboxyl-Terminal Hydrolase L1 of Cardiomyocytes Promotes Macroautophagy and Proteostasis and Protects Against Post-myocardial Infarction Cardiac Remodeling and Heart Failure

Ubiquitin Carboxyl-Terminal Hydrolase L1 of Cardiomyocytes Promotes Macroautophagy and Proteostasis and Protects Against Post-myocardial Infarction Cardiac Remodeling and Heart Failure

Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a deubiquitinase known to play essential roles in the nervous tissue. Myocardial upregulation of UCHL1 was observed in human dilated cardiomyopathy and several animal models of heart disease, but the (patho)physiological significance of UCHL1 in ca...

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Bibliographic Details
Main Authors: Penglong Wu, Yifan Li, Mingqi Cai, Bo Ye, Bingchuan Geng, Faqian Li, Hua Zhu, Jinbao Liu, Xuejun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
autophagy
cardiac remodeling
cardiomyocyte
myocardial infraction
Uchl1
ubiquitin
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.866901/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.866901/full

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